Latest (11) Full Text Articles (368) Focus on Sickle Cell Crises Article Summary

Assessing analgesic use in patients with advanced cancer: Development of a new scale--the analgesic quantification algorithm
Pain Medicine, 01/10/2014  Clinical Article

Chung KC, et al. – The authors assessed whether the Analgesic Quantification Algorithm (AQA) is more sensitive than the World Health Organization Analgesic Treatment Ladder (WHO–AL) for quantifying analgesic medication use among patients with advanced cancer. The AQA represents a more sensitive measure of analgesic use than the WHO–AL, and may better determine whether changes in pain assessments in clinical trials are due to the intervention or changes in analgesic use.


  • An expanded equianalgesic potency conversion table was developed to establish oral morphine equivalents for use in the AQA.
  • Categories of opioid use were selected to increase sensitivity within the higher dose range of opioids and to better capture increases in analgesic dose intensity.
  • The resulting 8–point AQA scale corresponds to no analgesic use, non–opioid analgesics, weak opioids only, ≤75 mg, >75–150 mg, >150–300 mg, >300–600 mg, and >600 mg oral morphine equivalents per day.
  • Baseline and 6–month analgesic data from a clinical trial of cancer patients were compared for each instrument.


  • At both time points, the 4–point WHO–AL demonstrated a ceiling effect with a clustering of patients in the strong opioid category, whereas the AQA resulted in a distribution of scores throughout the eight categories, including the five strong opioid categories.

► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Pain Management

See All >> Messages include industry-sponsored communications and special communications from PDR - powered by MDLinx

Most Popular Pain Management Articles

Last month's top read Top Articles of 2014

1 Deconstructing chronic low back pain in the older adult - step by step evidence and expert-based recommendations for evaluation and treatment Pain Medicine, April 7, 2015    Clinical Article

2 Are non-steroidal anti-inflammatory drugs effective for the management of neck pain and associated disorders, whiplash-associated disorders, or non-specific low back pain? A systematic review of systematic reviews by the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration European Spine Journal, April 8, 2015    Evidence Based Medicine    Review Article

3 Efficacy of inhaled cannabis on painful diabetic neuropathy The Journal of Pain, April 9, 2015    Clinical Article

4 Pharmacological treatment of migraine during pregnancy and breastfeeding Nature Reviews Neurology, April 3, 2015    Review Article

5 Predictors of postherpetic neuralgia in patients with herpes zoster: A pooled-analysis of prospective cohort studies from North and Latin America and Asia International Journal of Infectious Diseases, April 6, 2015    Clinical Article

6 Hypertonic dextrose injection (prolotherapy) for knee osteoarthritis: long term outcomes Complementary Therapies in Medicine, April 24, 2015    Clinical Article

7 Brain mechanisms of pain relief by transcutaneous electrical nerve stimulation: A functional magnetic resonance imaging study European Journal of Pain, April 3, 2015    Clinical Article

8 The effect of an acupressure backrest on pain and disability in office workers with chronic low back pain: A randomized, controlled study Complementary Therapies in Medicine, March 31, 2015    Clinical Article

9 Effectiveness of interventions designed to reduce the use of imaging for low-back pain: A systematic review Canadian Medical Association Journal, April 27, 2015    Review Article

10 Trends in opioid prescribing and co-prescribing of sedative hypnotics for acute and chronic musculoskeletal pain: 2001-2010 Pharmacoepidemiology and Drug Safety, April 27, 2015    Clinical Article

11 Effectiveness of transcranial direct current stimulation preceding cognitive behavioural management for chronic low back pain: sham controlled double blinded randomised controlled trial BMJ, April 27, 2015    Clinical Article

12 Long-term efficacy of a double-blind, placebo-controlled, randomized study for repetitive sphenopalatine blockade with bupivacaine vs saline with the Tx360® device for treatment of chronic migraine Headache: The Journal of Head and Face Pain, April 2, 2015    Clinical Article

13 Efficacy and safety of oral ketamine for the relief of intractable chronic pain: A retrospective 5-year study of 51 patients European Journal of Pain, November 25, 2014    Clinical Article

14 Episodic and chronic migraine headache: breaking down barriers to optimal treatment and prevention Headache: The Journal of Head and Face Pain, February 25, 2015    Clinical Article

15 Comparison of high-viscosity cement vertebroplasty and balloon kyphoplasty for the treatment of osteoporotic vertebral compression fractures: prospective assessment Full Text Pain Physician, April 1, 2015    Free full text    Clinical Article

16 Migraine and risk of ischaemic heart disease: a systematic review and meta-analysis of observational studies European Journal of Neurology, April 1, 2015    Review Article    Clinical Article

17 Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial Full Text The Journal of Headache and Pain, April 13, 2015    Free full text    Clinical Article

18 A comprehensive review of randomized placebo-controlled pharmacological clinical trials in children with functional abdominal pain disorders Journal of Pediatric Gastroenterology and Nutrition, April 28, 2015    Clinical Article

19 Peripherally applied opioids for postoperative pain: evidence of an analgesic effect? A systematic review and meta-analysis Acta Anaesthesiologica Scandinavica, April 28, 2015    Review Article

20 The effects of acupuncture treatment on the right frontoparietal network in migraine without aura patients Full Text The Journal of Headache and Pain, April 29, 2015    Free full text    Clinical Article

Indexed Journals in Pain Management: more

Other Topics in Pain Management

Register now to view all our site's content (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from our site and our sponsors
View Samples and Register